AB081. Effects of combination therapy of Tamoxifen, L-carnitine and daily PDE5 inhibitors in the Peyronie’s disease

نویسندگان

  • Jae Il Kang
  • Tae Yong Park
  • Hyeong Guk Jeong
  • Jong Jin Park
  • Ji Yun Chae
  • Jong Wook Kim
  • Mi Mi Oh
  • Hong Seok Park
  • Je Jong Kim
  • Du Geon Moon
چکیده

© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2016;5(S1) tau.amegroups.com and international index of erectile function (IIEF)] were analyzed. Results: Mean age of the patients was 56.9±11.2 years. Mean AR CAG repeat length and serum testosterone levels were 26.7±8.9 and 5.6±2.3 ng/mL, respectively. A Total of 64 men (26.6%) were diagnosed with MS and 22 men were diagnosed with LOH. Men with MS showed no significant difference in AR CAG repeat length compared with men without MS (P=0.325). AR CAG repeat length was not associated with HDL, LDL, triglyceride (P=0.397, P=0.609, P=0.867), but showed significant association with HbA1c (r=0.103, P=0.029). Men with LOH showed no significant difference in AR CAG repeat length compared with men without LOH (P=0.665). However as CAG repeat length was increased, AMS and PHQ scores were decreased and IIEF score was increased, significantly (r=−0.118, r=−0.153, r=0.069) (P<0.01, P<0.01, P<0.01). Conclusions: In conclusion, AR CAG repeat length seems to be associated with HbA1c and clinical symptoms of LOH in Korean male.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

AB093. The efficacy of medical treatment of Peyronie’s disease: Potaba monotherapy vs. combination therapy with Tamoxifen, L-carnitine, and PDE5 inhibitor

© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2016;5(S1) tau.amegroups.com important role during the occurrence and development of seminal vesiculitis. Methods: In the present study, we analyzed the expression of Sg I in normal seminal vesicle tissues and seminal vesiculitis tissues through immunohistochemistry. Results: The results showed down-regulated expres...

متن کامل

AB56. Current medical therapy for peyronie’s disease

Peyronie disease (PD) is characterized as a fibrous, inelastic lesion of the tunica albuginea. It is thought to result from trauma or microtrauma to the erect penis in genetically susceptible individuals, though the mechanism of disease has not been fully elucidated. The lesion can be painful in some individuals, and can also result in erection deformities making intromission difficult or impos...

متن کامل

The Effects of Tamoxifen in Combination with Tranilast on CXCL12- CXCR4 Axis and Invasion in Breast Cancer Cell Lines

It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...

متن کامل

The Effects of Tamoxifen in Combination with Tranilast on CXCL12- CXCR4 Axis and Invasion in Breast Cancer Cell Lines

It has been reported that CXCL12 binding to CXCR4 induces several intracellular signaling pathways, and enhances survival, proliferation, and migration of malignant cells. Herein we examined the effects of anti-estrogen tamoxifen and anti-allergic tranilast drugs as a single or in combination on invasion by two in vitro invasion assays, wound-healing and matrigel invasion on MCF-7 and MDA-MB-23...

متن کامل

The Comparison of the Protective Effect of L-Carnitine, Chromium and Vitamin D with Metformin on Liver, Antioxidant Enzyme Activity, and Iron Metabolism in Diabetic Rats

Objective: Due to the lack of information about the positive or negative effects of L-carnitine, chromium, vitamin D, and the uptake of a safe dietary supplement to reduce the effects of diabetes, it seems essential to determine the effects of these drugs on diabetes. Materials and Methods: Wistar rats were divided into 12 groups, control, diabetic, and intact, each of which was treated with m...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2016